Core Nutritional

Vitamin D3 + K2 Combination

💊 What it does

A combined D3 and K2 supplement addresses the two most important fat-soluble vitamins that work synergistically for bone and cardiovascular health. Vitamin D3 increases calcium absorption from the gut — K2 (as MK-7) then activates osteocalcin and matrix Gla protein to direct that calcium into bones and away from artery walls. Taking them together is more convenient and ensures the pair are present simultaneously.

👤 Who needs it

Anyone supplementing vitamin D3 at 25 µg (1,000 IU) or above who wants to ensure calcium is directed to bones rather than arteries. Post-menopausal women concerned about both bone density and cardiovascular health. People with a family history of arterial calcification.

🥦 Food sources first

Vitamin D3: very limited food sources (UV-exposed mushrooms, fortified plant milks). Vitamin K2 MK-7: natto (fermented soya) is by far the richest source, but rarely eaten in the UK. Both nutrients are difficult to obtain adequately from diet alone for people with limited sun exposure and no natto intake.

🗓 When to supplement

When supplementing vitamin D3 at 25 µg or above. As a convenient single-capsule alternative to buying both separately.

🏷 Best form to look for

Lichen-derived D3 paired with natto-derived MK-7 in a fat-soluble delivery base (olive oil or sunflower oil softgel). This combination ensures both are plant-based and in the optimal forms.

⏰ When to take it

With a meal containing fat — both are fat-soluble. Evening with dinner works well.

⚡ Interactions & combinations
Vitamin K2 interacts with warfarin and all anticoagulant medications — this is a contraindication to K2 supplementation without medical supervision. The D3 component increases calcium absorption — ensure dietary calcium is adequate.
🛡 Safety notes
Well tolerated at standard doses. The K2 component: anyone on warfarin or anticoagulants must not take without GP supervision.
🌿 Vegan note
Lichen-derived D3 and natto-derived MK-7 are both plant-based. Check that the capsule shell is vegetarian/vegan.
Strong evidence
Well-established by multiple high-quality clinical studies.
Sign in to track this supplement and include it in your daily nutrient totals.
Disclaimer: As with any supplement, it is best to consult with a healthcare professional before starting, particularly if you are pregnant, nursing, or taking prescription medications.