💊 What it does
Spermidine is a polyamine compound produced naturally by the body and found in many foods, particularly wheat germ. It activates autophagy — the cellular self-cleaning process that degrades damaged proteins and organelles, and is one of the primary mechanisms through which caloric restriction extends lifespan in animal models. Spermidine levels decline with age, and epidemiological evidence links higher dietary spermidine intake with longer life expectancy and reduced cardiovascular and cancer mortality. It is one of the most scientifically credible compounds in longevity research.
👤 Who needs it
People interested in longevity and cellular health. Older adults wanting to support autophagy. Those following caloric restriction mimetic protocols. Anyone interested in the intersection of nutrition science and ageing biology.
🥦 Food sources first
Wheat germ is by far the richest dietary source (approximately 2-3 mg per 100g). Other sources: aged cheese (especially long-aged varieties), mushrooms, soya products, chickpeas, peas, broccoli, and cauliflower. Regular wheat germ consumption (1-2 tablespoons daily) provides meaningful spermidine.
🗓 When to supplement
As a longevity supplement to support autophagy. In combination with intermittent fasting (which also activates autophagy) for synergistic effects. For people who do not eat wheat germ regularly.
🏷 Best form to look for
Wheat germ extract standardised to spermidine content. Spermine and spermidine trihydrochloride are used in research products. Doses of 1-6 mg/day are studied.
⏰ When to take it
Morning or with meals. Consistent daily use. Some protocols combine with intermittent fasting to maximise autophagic activation.