💊 What it does
Fisetin is a flavonoid found in strawberries, apples, and persimmons with emerging evidence as a senolytic — a compound that selectively clears senescent cells (dysfunctional cells that accumulate with age and drive inflammation). Senescent cell clearance is a key mechanism in longevity research. Fisetin is also a potent antioxidant, anti-inflammatory, and has demonstrated neuroprotective properties in animal studies. Early human trials are underway for age-related conditions. It is one of the most promising supplements in longevity research.
👤 Who needs it
People interested in longevity and healthy ageing. Those wanting senolytic support. Older adults with chronic inflammatory conditions. People interested in frontline longevity science willing to act ahead of full human clinical validation.
🥦 Food sources first
Strawberries are the richest dietary source of fisetin — several times more than other fruits. Apples, persimmons, grapes, onions, and cucumbers also contain fisetin. Regular strawberry consumption is a meaningful food-based source.
🗓 When to supplement
As part of a longevity-focused supplement protocol. For senolytic applications — some longevity researchers use fisetin intermittently (e.g. higher doses for 2-3 days per month) rather than daily, based on the senolytic mechanism. This is experimental.
🏷 Best form to look for
Liposomal fisetin or complexed with phosphatidylcholine has better bioavailability than standard powder. From Rhus succedanea (wax tree) or synthesised.
⏰ When to take it
With a fatty meal — fat enhances absorption. Some longevity protocols use intermittent higher-dose pulsing rather than daily low-dose supplementation.